Bortolasci CC, Voigt C, Turner A, Mohebbi M, Gray L, Dodd S, et al
The Bottom Line For patients and clinicians, the choice between these therapies depends on: Desired weight loss Convenience and preference (oral vs injectable) Tolerance of side effects Insurance and accessibility Retatrutide leads in efficacy but may bring more side effects
No Kate Knibbs: Yeah
Phentermine increases heart rate and blood pressure through sympathetic activation, while GLP-1 agonists like semaglutide can lower heart rate in some patients but increase blood pressure variability in others
Norepinephrine is critical for regulating mood, attention, cognitive focus, and the autonomic nervous system's response to stress
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