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In children, IGF-1 is essential for stimulating cell growth and differentiation, while in adults, it continues to exert anabolic effects, promoting tissue growth and maintenance

Nanomedicine 19, 57935812

Aksungar FB, Eren A, Ure S, Teskin O, Ates G

It typically occurs during treatment initiation or dose escalation and often resolves within several weeks as tolerance develops

Increased expression of VEGF stimulates angiogenesis, acting on dopamine D1 receptors, and may cause, among other things, dyskinesia, a major side effect of L-DOPA, which may further reduce the quality of life of PD patients under L-DOPA medication (Veith and Henderson 2019) Increased VEGF expression has been also documented in astrocytes, endothelial cells (ECs), and monocytes of MS patients, potentially contributing to BBB permeability and the onset of MS