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Samsonova et al., 2005) and PuuC, a non-specific aldehyde dehydrogenase that oxidizes all aldehydes in putrescine catabolism including -aminobutyraldehyde (Schneider and Reitzer, 2012)
Individuals with active MASHmarked by significant mitochondrial dysfunction and inflammatory activityrepresent a more susceptible population
2014;9:e82331 Geldenhuys W, Wehrung D, Groshev A, Hirani A, Sutariya V
Deficiency Lipoic acid deficiency has been described in rare cases of inherited mutations in the lipoic acid biosynthetic pathway
Future work will optimize non-invasive platforms (e.g., exosome-engineered carriers), as ICV remains a preclinical tool for mechanistic studies