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Although Bbs5 / mice showed no differences in body weight at weaning compared to age-matched WT or heterozygous littermate controls, the KO mice began gaining adiposity at a significantly faster rate after 4 weeks of age, eventually becoming visibly larger than mice in both control groups (Figure 1A) Bbs5 / mice exhibited significant hyperphagia in both the light and dark phases compared with WT controls (Figure 1B), leading to increased body weight from 8 weeks of age (Figure 1C) and fat mass compared with WT littermate controls starting from 6 weeks of age (Figure 1D)

Phase 2 Trial The NEJM Study That Started the Conversation Study: Jastreboff AM, Kaplan LM, Fras JP, et al

Hypoglycemia is a potential concern, particularly if you are on concurrent insulin or sulfonylurea medications

Your appetite signaling is recalibrating, your metabolic pathways are responding to the new input, and the compound is building toward its full therapeutic concentration

Its recommended that you keep your receipts and LOMN to ensure you get reimbursed if you pay out of pocket

[1] [4] In the type 2 diabetes cohort, retatrutide also produced clinically meaningful weight loss alongside reductions in HbA1c