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Adding GHK-Cu, optimizing minoxidil, or introducing PRP treatments at this stage addresses different bottlenecks that PTD-DBM alone cannot overcome

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In this scenario, it's acting locally before it's even absorbed systemically

In one example, GSH-driven nanoparticle disintegration releases indomethacin to inhibit PTGS2 while reducing Pt 4 + to cytotoxic Pt 2 + , thereby amplifying cisplatin-induced pyroptosis in pancreatic cancer 218