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The mean reduction in body weight at 48 weeks was 24.2% in the 12-mg group the largest reduction observed to date in a Phase 2 trial of an anti-obesity medication. Jastreboff et al., New England Journal of Medicine, 2023 The Liver-Fat Result Beyond weight loss, retatrutide produced a result that surprised researchers: dramatic reductions in liver fat

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Results showed that subcutaneous exenatide increased postprandial EF independently of glucose and triglyceride reductions