Flow cytometric analysis The separated leukocytes were stained with fluorescent-conjugated antibodies purchased from BioLegend, BD Biosciences (Franklin Lakes, NJ, USA), Thermo Fisher Scientific, and Tonbo Biomedicine as follows: anti-CD3, anti-CD4, anti-CD8, anti-CD11b, anti-CD11c, anti-CD45, anti-CD45R(B220), anti-CD95, anti-CD117(c-kit), anti-CXCR5, anti-FcRI, anti-GL-7, anti-IgE, anti-Ly6C, anti-Ly6G, anti-PD-1, and anti-Siglec-F (Supplementary Table 1)
For perimenopausal women noticing new weight gain or energy instability, a structured period of CGM can identify whether significant glucose dysregulation is occurring and guide dietary and lifestyle adjustments before the process advances to prediabetes
All participants will receive standard lifestyle recommendations, including physical activity, portion control, and self-monitoring of weight
There is even human evidence pointing the other way in some settings, such as inflammation, where GLP-1 rises
The SURPASS-1 through SURPASS-5 trials demonstrated that 91% of patients on tirzepatide achieved an A1C below 7% (the standard treatment target), compared to approximately 68% on liraglutide in comparable studies
It contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)