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A growing set of evidence suggests that using semaglutide could lead to decreased substance use, and a large new study shows a promising link between the medication and tobacco use

3.5 Metagenomic analysis demonstrates that SE reshapes the gut microbiome and its metabolic function To investigate the origin of the altered bile acid profiles, we performed shotgun metagenomic sequencing of fecal samples

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doi: 10.1371/journal.pone.0054087 105 MajbourN

The cardiovascular benefits extend further: semaglutide has been shown to reduce the risk of heart attack and stroke in people with obesity and type 2 diabetes

They work by slowing stomach emptying, curbing food noise and cravings, and improving metabolic response, but they also introduce a unique routine of weekly shots, fluctuating medication levels and side effects that ebb and flow over the course of the week