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Continuous, uninterrupted GHRH stimulation leads to receptor downregulation over time, reducing the efficacy of the peptide

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BMJ Open 9 , e026677 (2019)

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While fewer trials have studied combinations of non-drug treatments, the reasoning is the same: therapies such as light therapy, shockwave therapy, electrical stimulation, vibration therapy, spinal decompression, and supplements all affect different parts of nerve health

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10.1038/s41569-018-0098-5 5 AhernT

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The microneedling overcomes the topical delivery challenge that the review identifies getting GHK-Cu to the dermal papilla cells identified by the gene data as key targets

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