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Twenty compounds for each binding site displaying the best binding interactions were selected for antiplasmodial activity testing (Supplementary Table S4)

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112,114,118120 Therefore, oxidants will overwhelm cellular antioxidant systems, leading to mitochondrial membrane permeability transition pore opening 121,122 and mitochondrial dysfunction that are concurrent with extensive oxidative damage to proteins, DNA, and lipids 123127 (Figure 5)

doi: 10.3389/fvets.2024.1383801 31 HeJ.ZhangP.ShenL.NiuL.TanY.ChenL.et al