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however, since both receptors share a high degree of structural and functional homology, the IGF1R can bind insulin and the IR can bind the IGFs with reduced affinity

This post covers the part that matters just as much: how much, how often, and how to actually use it

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Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al

Human trials are still limited, so we use them carefully and with full informed consent