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Arch Pediatr Neurosurg

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Key Analytical Concerns Solubility-related variability Non-covalent molecular association Aggregate formation Stability-indicating method validation Aggregation analysis is particularly important because molecular aggregation can affect: Product potency Pharmacokinetics Immunogenicity risk Long-term formulation stability Combining size exclusion chromatography (SEC) with MS-based analytical techniques significantly improves aggregate characterization and stability assessment accuracy

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Patients were followed for 108 weeks

Neither medication is a standalone solution for weight loss