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The severe lung dysfunction that characterizes the disease is due to an alteration in an ion transport protein, CF transmembrane conductance regulator (CFTR)

Molecules 22 , 1529 (2017)

Some patients may also have underlying female pattern hair loss, PMOS, thyroid disease, low ferritin or autoimmune hair loss that becomes more apparent during weight loss

Figure 1: Scatter Plot and Fitted Line of Change from Baseline in 24-Hour Urinary Glucose Amount versus Dapagliflozin Dose in Healthy Subjects and Subjects with Type 2 Diabetes Mellitus (T2DM) (Semi-Log Plot) Saxagliptin In patients with type 2 diabetes mellitus, administration of saxagliptin inhibits DPP-4 enzyme activity for a 24-hour period

These elements operate in the background, sometimes creating resistance to weight loss without any obvious cause

VDRA = vitamin D receptor agonist