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It is NOT more serious than any other cause and apart from a deficiency caused by a proven dietary lack, treatment by injection is required for the swiftest recovery

[3] The doses used in these tendon studies typically ranged from 10 to 200 micrograms per kilogram of body weight, administered once daily, which when extrapolated to a 75-kilogram human would suggest a working range of approximately 200 to 500 micrograms per day

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These effects can happen more often with larger peptides, hydrophobic peptides, basic peptides, or solutions prepared at very high concentration