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Follow the dosage escalation in Table 2 to reduce the risk of gastrointestinal adverse reactions [see Warnings and Precautions (5.6), Adverse Reactions (6.1)]

doi: 10.1021/ml300307b

Possible symptoms some individuals may notice include: Nausea or stomach discomfort Bloating or increased stomach sensitivity Dizziness or light-headedness Fatigue or sleepiness Appetite changes Blood sugar fluctuations Vomiting or diarrhoea linked to Wegovy may also increase dehydration risk if fluid intake becomes too low

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Common types of MC4R dysfunction Many variants (e.g., Ser127Leu) exhibit multiple concurrent functional defects, and the majority follow a dominant inheritance pattern consistent with haploinsufficiency [29]

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