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Major inhibitors relating these immunoreceptors, in the format of monoclonal antibodies, include PD-1 inhibitors nivolumab, pembrolizumab and sintilimab, PD-L1 inhibitor atezolizumab and durvalumab, and CTLA-4 blocker tremelimumab and ipilimumab, etc

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Thus, returning to the example of gilts during the peri-estral period, it appears that the prooxidative conditions brought about by ovulation upregulated the GSH system