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These findings detail mechanisms of NRF2-dependent transcriptional regulation, pointing to noncanonical roles that extend beyond augmenting antioxidant capacity

Diseases with an autoimmune component damage particular cells mitochondrion

For example, kynurenine restrains melanoma and endothelioma cellular proliferation [136, 137], impairing DNA synthesis and inducing necrosis in melanoma cells, while promoting the -catenin pathway and colon cancer cells multiplication in a dose-dependent manner [138]

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