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They don't typically cause the same kind of facial purging because they're not being applied directly to congested facial skin

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Melanotan I (MT-1) is a linear first-generation alpha-MSH analogue studied for more selective melanocortin activity, whereas Melanotan II is a cyclic analogue studied for broader melanocortin receptor activity

Curr Neuropharmacol 4:233237 Janiri L, Falcone M, Persico A, Tempesta E (1991) Activity of l-carnitine and l-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo