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For bodybuilders maintaining high protein intake (1.0-1.4g per pound of lean mass), consistent heavy training, and adequate recovery, lean mass loss can be significantly less

From Stuck to Steady Progress: A 16-Week Stack Experience I had been running Retatrutide solo for about 10 weeks when I hit what felt like a wall

Summary: GLP-1 receptor agonists can produce clinically significant weight loss without structured exercise, though combining medication with physical activity optimises outcomes and preserves muscle mass

The prescribing information for all GLP-1 medications explicitly states that missed doses should not be compensated for by increasing subsequent doses