mercury glutathione Methylmercury alters homeostasis by inhibiting glutaredoxin 1 and enhancing glutathione biosynthesis in cultured human astrocytoma cells Warning Out on Thailand-Made Skin

S3 and Table S1a

The only human trial ever registered (NCT02637284) was cancelled in 2016 without publishing results

Mechanistically, stabilization of wild-type p53 and induction of the p53 target gene CDKN1A (p21) leads to decreased expression of the ribonucleotide reductase (RNR) subunits RRM1 and RRM2

In the circulation, platelets and components of the coagulation system support tumor cell survival by protecting them from cytotoxic immune cell recognition

& Henson, F

Analogs such as 6-diazo-5-oxo-l-norleucine (DON) and acivicin did show cytotoxic effects against several tumor types, including leukemia and colorectal cancers