312,313,314,315 Maintaining this calcium homeostasis is fundamental to calcium signaling, and disruption in cytosolic calcium concentration gradients, as well as abnormalities in calcium signaling pathways, may lead to neurodegenerative diseases such as AD and Parkinsons disease (PD), cardiovascular diseases, and metabolic disorders
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There are GLP-1 clinical trials focused on both obesity and type 2 diabetes
Notably, AD and DM share numerous pathophysiological mechanisms, most notably the disruption of insulin signaling pathways in the brain
Acta Neuropathol (Berl)