Limitations, Long-Term Considerations, and When to Consider Phentermine-Topiramate Even though it works well, phentermine has important limitations: FDA approval remains limited to short-term use Appetite suppression may diminish over time (tolerance) Not ideal for patients with uncontrolled anxiety, insomnia, or hypertension Does not improve metabolic markers (A1C, cholesterol) like GLP-1 therapies For longer-term taste control, combination options such as phentermine-topiramate may offer more sustained benefit under medical supervision
Gut abnormalities persist even in Crohn's remission by Doug Brunk Multi-omics analysis reveals ongoing epithelial and microbial disruption despite effective immune suppression
Bernstein analyst Courtney Breen said the FDAs decision suggests that the end of compounder-spree was near, but that this will have only a modest impact on the drugs prescription volumes in 2025
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The dosage of the medication is tailored by a specialist based on your medical history and weight loss goals
A confirmatory analysis also showed that 33% of patients in the semaglutide group achieved both endpoints (resolution of steatohepatitis and improvement in fibrosis) compared with 16% of those receiving placebo
