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Sethi and others have demonstrated safety and efficacy in mixed psychiatric populations, including depression and bipolar disorder and schizophrenia

However, STEP 1 extension concluded that 1-year withdrawal of semaglutide results in regain of two-thirds of prior weight loss [97], highlighting that withdrawal of semaglutide results in weight regain which may be problematic in older adults who are already using polypharmacy approaches for comorbid disease

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