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Growth hormone production peaks in adolescence and declines through adulthood, and IGF-1, the downstream messenger that drives muscle protein synthesis and tissue repair, declines along with it

Clarke WL, Cox DJ, Gonder-Frederick LA, Julian D, Schlundt D, Polonsky W (1995) Reduced awareness of hypoglycemia in adults with IDDM

On a chow diet, adipocyte-specific loss of Bmal1 impaired glucose tolerance and caused compensatory hyperinsulinaemia, which was normalized by NDI1 (Extended Data Fig

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