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doi: 10.1016/j.jse.2019.12.002 Summary Keywords gastric distension, intestinal distension, glucagon-like peptide-1, vagal afferents, food intake, insulin sensitivity, obesity, feeding rhythm Citation Ohbayashi K, Oyama Y, Yamaguchi C, Asano T, Yada T and Iwasaki Y (2021) Gastrointestinal Distension by Pectin-Containing Carbonated Solution Suppresses Food Intake and Enhances Glucose Tolerance via GLP-1 Secretion and Vagal Afferent Activation

More research is needed to guide decisions about the use of these medications in complex patients, especially when considering long-term therapy

Two experiments were conducted, a Dose-finding experiment involving 3 treatment weeks with the b S1 v S2 meal schedule, and the Meal schedule experiment involving 4 treatment weeks, one for each of the 4 meal schedule conditions

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These findings uncover a non-canonical mechanism of action for GLP-1 analogs, highlighting a specific microbiota-endocannabinoid metabolic pathway as a potential therapeutic target for depression.

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