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8 weeks 4 x 10 mL bottles Adds margin for losses and spare reconstitution

The medication works by mimicking a natural hormone that regulates hunger, helping to reduce cravings and increase feelings of fullness

No significant functional changes expected yet

STEP (semaglutide) Clinical Trial: Most loss from fat mass

The fluorescence signal can be easily detected using a fluorescence microplate reader at Ex/Em = 490/520 nm

Currently approved and commonly used GLP-1R agonists include exenatide (the synthetic form of Ex-4, a naturally occurring GLP-1R agonist), lixisenatide, dulaglutide liraglutide and semaglutide ( Figure 2 ) (17, 110)