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For example, genetically modified immature DCs expressing tolerogenic factors such as TGF-1 and Fas ligand (FasL) have shown promise in enhancing immune tolerance in liver transplantation models (43)

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Therefore, a higher rate of damaged protein routing to macroautophagy is accompanied by lower productivity of the cytosolic UPS but increased GRP78 function and NRF2-mediated effects at the same time