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Biofilm is a group of microorganisms that attach to a surface forming a three-dimensional structure containing a protective polymeric matrix, which renders them highly resistant to antibiotics [1]

So retatrutide produces the most weight loss in the shortest time, but the GI burden is higher, especially during dose escalation

Thus, while it is conceivable yet not statistically confirmed that semaglutide could cause AKI in selected patients, there is plenty of evidence that it reduces nephropathy in the long term