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Most meniscal tears do not heal because they are in an anatomic area that has no blood supply

doi:10.12688/f1000research.9845.1 Sniderman AD, Thanassoulis G, Glavinovic T, et al

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showed that FOXO4 expression is upregulated in irradiated-induced senescent IMR90 cells and that the protein binds to p53, inhibiting the role of this last one in apoptosis induction