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Science 368 (6486), 8589
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Effectiveness depends on the goal and the formulation
N.ahinF.et al (2021)
A longer half-life is a pharmacokinetic property, not evidence of a better or safer outcome
As for the patient base, a recent report found that 75% of patients stop taking the medications within two years, although the report did not elaborate on the causes of this decline in use, which may be partially attributable to factors such as high costs and self-funding requirements
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