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GHK (Gly-His-Lys) without copper is a simple tripeptide with a strong affinity for Cu(II) ions (log stability constant ~16.2), while GHK-Cu is the pre-formed 1:1 copper-peptide complex with distinct biological activity profiles

doi: 10.3389/fpubh.2020.00095 120 LiY.ZhangQ.WinterbothamM.MoweE.GorringeA.TangC