The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course
Li LS, Chiroma SM, Hashim T, Adam SK, Mohd Moklas MA, Yusuf Z, Rahman SA (2020) Antioxidant and anti-inflammatory properties of Erythroxylum cuneatum alkaloid leaf extract
For the full synergistic benefit of the Glow Stack, subcutaneous administration delivers both peptides systemically
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Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins
On the other hand, denatured whey protein undergoes processing that disrupts its natural structure