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They are sensed by L cells via FFAR2/GPR43 and FFAR3/GPR41, and activation of these receptors triggers GLP-1 secretion (51)

Regardless of the method used to produce a compound, the journey from discovery to clinical application of therapeutic peptides is filled with challenges, particularly in production and analytical characterization

GLP-1 medications have changed the game for adults managing obesity and type 2 diabetes

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While they did not investigate the directional sensitivity of the cerebral circulation in this study, their findings do support adaptation in the inherent directional sensitivity of the cerebral pressure-flow relationship