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This binding is independent of the bisphosphatase activity of TIGAR, suggesting that the regulation of the PPP by TIGAR is both phosphatase dependent and independent

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doi: 10.1007/BF00297496

This means it directly blocks one receptor (PCFT) and also increases UMFA, which blocks the main FR receptor

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However, a recent meta-analysis also revealed increased levels of CXCL8, CXCL12, CXCL16, and CCL5 (CC motif chemokine ligand 5), highlighting the complexity of the immunological landscape in vitiligo 37