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Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, et al

A pharmaceutical company sponsors a drug through preclinical testing, Phase 1 (safety), Phase 2 (dosing and efficacy), and Phase 3 (large-scale efficacy) clinical trials

20,287 Deleting SLC39A14 in TFR knockout mice significantly reduces hepatic iron accumulation, and inhibits ferroptosis-mediated liver fibrosis in high iron-diet mice

However, more studies are needed to fully understand its potential benefits and risks (4)

doi: 10.1186/s12943-024-02217-2 218 ChenLWenYXiongJChenYChenCB

Optimal dosing, frequency, and duration are completely unclear