Dihexa may also connect with intracellular signaling pathways
That said, the compound has not been through full Phase III trials or FDA drug approval
Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart AH, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD, Croitoru K, Crohns and Colitis Canada Genetic Environmental Microbial Project Research Consortium
Patients were to be randomized to 1200 mg, 450 mg, or placebo, administered intravenously daily for 3 days followed by weekly for 4 weeks
Some research has explored additional peptides for pain-related applications, though evidence bases vary and outcomes depend heavily on the individuals condition and protocol
For example, heavy rainfall can leach cobalt from the topsoil and make it more difficult for it to be available to grazers