Hair quality improvements are more commonly observed after the second cycle
NEJM 2023: 10.1056/NEJMoa2301972 Phase 2 dose-response (1, 4, 8, 12 mg arms, 48 wk, non-diabetic obesity)
That yields 2.5 mg/mL, which means 0.1 mL on a 1 mL insulin syringe (10 units on a U-100 scale) delivers 250 mcg
Continuous, multi-month use is widely discouraged because of progressive insulin resistance, organ-growth concerns, and IGF-1 receptor desensitization
Higher ("pharmacologic") doses are required to produce significant acceleration of growth in these conditions, producing blood levels well above normal ("physiologic")
resistance training 23/week