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doi: 10.1146/annurev.pathol.4.110807.092150 23 ChenXHanYGaoPYangMXiaoLXiongXet al
Not as a standalone intervention
At the population level, GLP-1RAs have been shown to enrich SCFA-producing genera including Roseburia and Ruminococcus and promote Akkermansia muciniphila colonization (a bacterium whose bioactive protein P9 independently stimulates further GLP-1 secretion) while simultaneously suppressing pathobionts including Escherichia coli and Enterococcus by reducing endotoxemia and restoring barrier function
Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v): results of a phase 3, open-label, randomised trial
It allows two independent receptor pathways to be stimulated simultaneously in preclinical models and the resulting potentiation of GH release to be measured
Thorburn, A
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