Clinical trials such as the STEP 1 study demonstrated significant weight reductiontypically 14.9% of body weight over 68 weeks compared with 2.4% with placeboalongside improvements in cardiovascular risk factors
Ig Sanita Pubbl 62:677696 Roxas JL, Viswanathan VK (2018) Modulation of intestinal paracellular transport by bacterial pathogens
Hepatitis delta virus antigens trigger oxidative stress, activate antioxidant Nrf2/ARE pathway, and induce unfolded protein response
If sleep disturbances persist, discussing this with a healthcare professional is important, as sleep disorders such as sleep apnoea may require specific treatment
doi:10.1152/japplphysiol.00141.2010 Baguet, A., Everaert, I., Hespel, P., Petrovic, M., Achten, E., & Derave, W
Recent research surprisingly demonstrated that serotonin-secreting enterochromaffin cells were the major chemical sensors for vagal afferent neurons in the proximal duodenum, whereas Glp1r -expressing ND neurons predominantly innervated muscle layers of the stomach and responded to stretch rather than to chemical stimuli entering the duodenum 46
