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reported increased TNF-, VEGF, CD31, and TGF- in IC/BPS patients with and without Hunner lesions compared with controls, whereas increased mast cell tryptase and collagen were observed in Hunner lesion patients only (compared with nonHunner lesion patients and controls)

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The copper-complex form is the biologically active species in most published research contexts the free tripeptide acquires copper from endogenous sources in physiological conditions, but in most research applications the pre-formed complex is what is used