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It appears to affect multiple neurotransmitter systems and has been shown to influence serotonin, dopamine, and GABA systems

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FoxO1-deficient -cells lose their identity and revert to pancreatic endocrine progenitors characterized by expressing high levels of neurogenin-3 (Neurog3 high ), and no insulin and MafA expression 22

Bile acid sequestrants: a review of mechanism and design