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Washington DC: US Environmental Protection Agency

H.GuoW.WangP

Results Outcomes reported in 30 trials suggested that MMS improves micronutrient status, leads to a healthier reproductive environment during preconception, and can significantly reduce neural tube defects and congenital abnormalities in early pregnancy above and beyond supplementation with folic acid alone

It has also been suggested that an increased luminal bile salt concentration would have an osmotic effect, which could lead to the diarrhoea associated with metformin treatment [72]

S., Aggarwal, N