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"For example, you may be doing well at 5 mg, so that could be your long-term dose rather than continuing to increase the dosage." Zepbound dosing Zepbound, the version approved for weight loss, comes in the same six dosages as Mounjaro: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg and is usually increased at a similar pace: Week 1-4: 2.5 mg Week 5-8: 5 mg Week 9-12: 7.5 mg Week 13-16: 10 mg Week 17-20: 12.5 mg Week 21-onward: 15 mg "Similar to Mounjaro or other GLP-1 medications, you'll be closely monitored to see how well you do on a specific dosage, and that will tend to determine if you increase," says Sowa