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A trial published in the New England Journal of Medicine revealed that retatrutide helped patients achieve significant weight loss

HRT doesnt directly cause weight loss, but it restores the hormonal baseline needed for better metabolic health

The mechanism difference explains the gap

Neither medication is currently available in Canada through traditional channels, though Mazdutide has already received regulatory approval in China and sits closer to global market availability

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For a 200 lb person, Retatrutide would produce approximately 48 lbs of weight loss on average, compared to 42 lbs with Tirzepatide