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Experimental procedure The rats were randomly allocated into five groups as follows: The control group underwent a sham operation and received subcutaneous (S.C.) injections of 44 mM sodium phosphate dibasic, 70 mM NaCl + 0.007% Tween 20 for 10 weeks once weekly

The primary endpoint is the time to the first occurrence of a composite primary outcome event, defined as a persistent eGFR decline (50% from baseline), reaching ESRD, renal death, or CV death

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(2025) reported that over a 72 week period of use that Mounjaro could be responsible for a reduction in muscle mass of 10.9% (the equivalent of 5 years of aging) Supervised programs enhance fat loss while preserving muscle better than unsupervised exercise (Hansen et al., 2020)