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Such alterations have been observed in conditions including major depressive disorder, chronic fatigue syndrome, burnout, post-traumatic stress disorder (PTSD), and anxiety disorders

S.et al (2010)

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In animal and in-vitro research it has been investigated for effects on tendon, ligament, muscle, and gut-tissue repair, where it appears to promote angiogenesis (new blood-vessel formation) and accelerate cellular healing

181 HIF-1 also cooperates with other transcription factors to regulate autophagy

Psychol Med 43:471481 Fornaro M, Martino M, Battaglia F, Colicchio S, Perugi G (2011) Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation