Because glutathione is a peptide (a small protein), the enzymes in your digestive tract, specifically peptidases , often recognize it as food rather than a supplement
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Consumer Results 99% agreed it instantly nourished skin with moisture, imparting a smooth, healthy-looking glow 96% agreed skin looks nourished** 95% agreed skin feels deeply moisturized** 95% agreed skin feels immediately hydrated** 94% agreed skin looks and feels healthier** 94% agreed skin feels smoother and more supple** 93% agreed skin looks and feels softer** 93% agreed it improved the overall appearance of skin** 91% agreed skin looks radiant** 88% agreed they love the non-sticky, non-greasy formula** 87% agreed it absorbs quickly into the skin** 81% agreed skin looks and feels more plump** 81% agreed it softens fine lines and wrinkles** 80% agreed skin feels firmer** 79% agreed skin looks firmer** 79% agreed it improves skins elasticity** 78% agreed it dramatically improves skin complexion** 77% agreed it dramatically improves skin texture** 76% agreed skin doesnt feel oily after application** ** In a consumer study of 106 women after 28 days

(Reference Kumar, Liu and Suliburk22) supplementing 100 mg/kg/d GLY and CYS, provided as N-acetylcysteine (100 mg/kg/d), improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation and physical function
Indigo seems to take a more holistic approach
Glutamine-induced secretion of intestinal secretory immunoglobulin a: a mechanistic perspective
(PubMed) Higdon JV, Delage B, Williams DE, Dashwood RH