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[DOI] [PMC free article] [PubMed] [Google Scholar] Grill HJ

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In a further set of experiments, IBMX (at a higher dose) was added only for the final 10 min out of the 16 h incubation for a point estimate of cAMP synthesis rate

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In addition, arginine, a substrate for the generation of endogenous nitric oxide, is degraded by arginase, which is formed from ruptured red blood cells

The timeline question of when side effects begin varies by individual but most people notice GI effects within the first few days of each dose increase