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10.1186/s13287-024-04013-7 135

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This analytical gap has encouraged us to develop a new analytical protocol based on HPLC technique and UV detection to control the concentration of N-Hcy-Lys and related aminothiols, such as Cys, GSH and Hcy in human plasma

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Mechanistically, DMF regulates the expression of factors involved in the de novo cysteine synthesis (CBS), cystine uptake (SLC7A11), and GSH generation (GCLC, GCLM) through NRF2-dependent and independent pathways