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Therefore, identifying molecular targets that are shared between the two drugs is crucial, as it will provide some understanding of the pathogenesis of bipolar disorder, and inform the development of new, mechanism-based therapies with improved efficacy and better side-effect profiles [161]

Additionally, we observed that Ex-4c stimulated GLP-1Rs and activated the protein kinase A (PKA)-dependent signaling pathway, which in turn closed putative adenosine triphosphate-sensitive K + (K ATP ) channels, leading to the depolarization of POMC neurons

Prevalence The prevalence of HFimpEF has been described in the literature but varies significantly due to the differences in population and definition, ranging from 9 to 52% 1,2,3,4

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Dec 2001;1(6):529-39